DEAR DR. MICHELLE,
Is it true that a molecule found in green tea breaks up tau tangles seen in Alzheimer’s disease?
Yes, a molecule in green tea called epigallocatechin gallate – shortened to EGCG – has been shown to untangle tau tangles that form in Alzheimer’s and even stop them from spreading. These tangled fibers lead to brain cell death and the related functional decline we see in people who have Alzheimer’s disease.
Unfortunately, this does not mean that drinking green tea will lead to a reduction in tangles and functional decline. Studies showing the positive effect of EGCG were conducted in laboratories where the EGCG molecule was directly applied to the tangled fibers. In a living person, the EGCG molecule does not penetrate into the brain easily and may also bind to proteins other than tau, weakening its potential effect on tau tangles.
Researchers at UCLA are using computer modeling techniques to identify other molecules that are similar to EGCG that may enter the brain more easily. As new molecules are discovered, they can be tested for their potential treatment benefits. So, while your next cup of green tea may not offer a cure for Alzheimer’s, the promise of another cohort of disease-modifying therapeutics may be floating within.
DEAR DR. MICHELLE,
I’m in my 50s and starting to worry about my memory. I am a busy, high-functioning person, but wondering if I should be taking any additional steps at this time?
I’m a firm believer of: “If in doubt, check it out.” Just like we are urged to have regular screenings for things like hearing, vision, dental health, the same should be true for brain health, especially beginning in the 50s. I recommend that you speak with your doctor and ask to be referred for cognitive screening.
Next month – November – is National Alzheimer’s Awareness month. There are likely to be cost-free screening and educational events throughout the area. Check the internet, as well as local publications and organizations for some possibilities near you. A cost-free screening could be a great place to start.
*Michelle Papka, Ph.D. is the Founder of The Cognitive and Research Center of New Jersey (The CRCNJ) in Springfield, NJ. The mission of The CRCNJ is to provide no-cost diagnostic, treatment and supportive resources through clinical research opportunities to people affected by Alzheimer’s disease and other cognitive disorders.
