Current Trials
ACTIVE CLINICAL STUDIES AT THE CRCNJ
To find out if you’re eligible, contact us at 973 850 4622 or click on the link to the trial of interest, complete the online form, and we will contact you.
Actively Enrolling
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 76-Week Study Evaluating The Safety And Efficacy Of Two Doses Of Simufilam In Subjects With Mild-To Moderate Alzheimer's Disease
SPONSOR: Cassava Sciences, Inc
A 76-week safety and efficacy study of simufilam (PTI-125) given twice daily to participants with mild-to-moderate Alzheimer's disease (AD) for 76 weeks. Approximately 1083 participants will be randomized (1:1:1) to receive either placebo, 50 mg tablets of simufilam, or 100 mg tablets of simufilam, twice daily, for 76 weeks. Clinic visits will occur 4 weeks after the baseline visit, and then every 12 weeks until the end of the study. The safety of simufilam, and its efficacy in enhancing cognition and slowing cognitive and functional decline will be evaluated.
clinicaltrials.gov.
A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study)
SPONSOR: Cognito Therapeutics
This is a randomized, double-blind, sham-controlled, adaptive-design pivotal study of sensory stimulation in subjects with mild to moderate Alzheimer's disease. Approximately 345 subjects will be randomized to 12 months of daily treatment with either Active or Sham Sensory Stimulation Systems. Efficacy will be measured using the Alzheimer's Disease Cooperative Study- Activities of Daily Living (ADCS-ADL) assessment and a combined statistical test (CST) of the ADCS-ADL and the Mini-Mental State Exam (MMSE).
clinicaltrials.gov.
A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1)
SPONSOR: Eli Lilly
TRAILRUNNER-ALZ 1 is a Phase 3, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of remternetug in participants with early symptomatic AD. Participants will receive remternetug or placebo administered via subcutaneous injection or intravenous infusion.
clinicaltrials.gov.
A Donanemab (LY3002813) Prevention Study in Participants With Alzheimer's Disease (TRAILBLAZER-ALZ 3)
SPONSOR: Eli Lilly
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD).
clinicaltrials.gov.
Coming Soon to The CRCNJ
A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease (ENVISION)
SPONSOR: Biogen
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.
clinicaltrials.gov.
Active But Closed to Enrollment
A Phase 3, Open-Label, Parallel-Group, 2-Arm Study to Investigate Amyloid Plaque Clearance with Donanemab Compared with Aducanumab-avwa in Participants with Early Symptomatic Alzheimer’s Disease
SPONSOR: Eli Lilly
The TRAILBLAZER-ALZ 4 Study will compare how safe and effective two drugs are at removing amyloid plaque in people with early stages of Alzheimer’s disease – an investigational drug and a drug already FDA-approved to treat this condition. Both the investigational drug and the FDA-approved drug are given through a tiny tube into your vein (called an “infusion”). All participants will receive either the investigational drug or the FDA-approved drug.
trailblazer4study.com.
CLOSED TO ENROLLMENT
Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease
SPONSOR: Eli Lilly
The reason for this study is to see how safe and effective the study drug Donanemab is in participants with early Alzheimer's disease. clinicaltrials.gov.
For additional information, click here.
CLOSED TO ENROLLMENT
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
SPONSOR: Eli Lilly
The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease.
clinicaltrials.gov.
CLOSED TO ENROLLMENT
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